Improved thyroid function in oncological patients with
Hashimoto Thyroiditis treated with Immunomodulators
Francesco Matozza MD, Guillermo H. Artero Ph, Guillermo E. Artero MD, Monica Rodriguez Laborda MD
Keywords: hashimoto thyroiditis-Immunomodulators-cancer-thyroid function
Francesco Matozza Is Oncologist in Buenos Aires .
Guillermo E. Artero is Physician at Tornu Hospital in Buenos Aires
Guillermo H Artero is Pharmacist in Pharmaceutical Industry in Buenos Aires, Argentina
Monica Rodriguez Laborda is psychoimmunoendocrinologist in Buenos Aires
Contact
F.Matozza M:D. frankmatozza@libero.it
G.H.Artero Ph arteroguillermo@fibertel.com.ar
| NOTA IMPORTANTE. Questo articolo ha uno scopo esclusivamente informativo. Ogni sforzo è stato condotto per renderlo chiaro, aggiornato, facilmente comprensibile da un pubblico molto vasto; tuttavia non possiamo escludere eventuali omissioni ed errori come anche possibili difficoltà interpretative da parte dei lettori. La Medicina è una scienza in costante evoluzione ed ogni paziente è unico nella sua condizione clinica; ribadiamo quindi che è solo il vostro Medico Curante che può illustrare la particolarità e quindi la prognosi della vostra condizione e che a lui solo spetta ogni conclusione diagnostica e terapeutica. Non rispondiamo in alcun modo di un uso improprio e non autorizzato delle informazioni fornite. Ultimo aggiornamento: 18.9.2006 . |
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Introduction
Hashimoto's thyroiditis is chronic autoimmune inflammation of the thyroid with lymphocytic infiltration
The destruction of the thyroid gland occurs through the action of CD8 positive killer T cells. CD4 positive helper T cells and B cells are also identified in the thyroid glands of patients with Hashimoto thyroiditis
Hashimoto's thyroiditis is the most common cause of primary of hypothyroidism The disease is 7 times more frequent in women.
The incidence of Hashimoto thyroiditis worldwide is estimated to be 0.3-1.5 cases per 1000 of population per year
Incidence increases with age and in patients with chromosomal disorders, including Turner's, Down, and Klinefelter's syndromes. A family history of thyroid disorders is common.
An increased incidence of cancer is seen in people with an autoimmune disease.
The treatment of Hashimoto thyroiditis consists of replacing thyroid hormone with levothyroxine, when the patients have become hypothyroid.
Purpose.
The aim of the study was to evaluate the improvement in thyroid function as well as quality of life in oncological patients with Hashimoto Thyroiditis treated with Immunomodulators
.
Material
We retrospectively review in a multicentric study, 161 patients with Hashimoto thyroiditis, and different types of tumors (breast, kidney, ovarian, uterus, colorectal, thyroid, lung, pancreas, larynx, stomach, bladder, prostate, etc).
Age range 40 to 70 years old.
98 patients were treated with (chemotherapy or radiotherapy) + levothyroxine and Immunomodulators during 6 month.
This Immunomodulators compound contains: Astragalus Ext., Zinc, Mg and Selenium.”
63 patients treated only with oncological treatment (chemotherapy or radiotherapy) + levothyroxine as a control group.
Method
Thyroid function: T3.T4. TSH, TPO and TG antibodies were measured before, during and after six month treatment with Immunomodulators treatment.
Immunomodulators was administered orally sublingual at a dose of 4ml / day
In the control group the thyroid function was evaluated every four month
Result
87 patients (78.5 %) treated with Immunomodulators showed increase T3, T4, and diminution of TSH, TPO and TG after 2 month of treatment.
These patients required less levothyroxine than there were taken before.
8 patients (8.16%) did not show changes in their thyroid function.
3 patients (3.06%) withdrew the treatment
We also observed a better quality of life in these patients. (Increase WBC, RBC).
Less fatigue, dry skin, depression, Cold Intolerance,
In the control group the thyroid function as well as the antibodies did not show any changes.
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Clinical implication
Immunomodulators improves thyroid function in patients with Hashimoto thyroiditis
No side effect were seen in this patients
IM treatment is safe and well tolerated
In cancer patients with Hahimoto thyroiditis IM also improve, RBC, WBC, platelets and the disease free survival period.
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